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Figure 7


Fig. 7. ZM3 inhibits spindle bipolarity. DLD-1 cells were exposed to MG132 plus either 2 µM ZM1, 2 µM ZM3 or monastrol (Mon) for 2 hours, then analysed by immunofluorescence. (A) Images showing examples of monopolar spindles in the presence of monastrol and ZM3. Bar, 5 µm. (B) Bar graph quantifying monopolar spindles. The values represent the mean ± s.e.m. derived from three independent experiments in which at least 100 mitotic cells were scored. (C) Dot plot showing interpolar distances. (D) Line graph showing proportion of monopolar spindles over a range of ZM concentrations. The data are derived from a single representative experiment in which at least 100 mitotic cells were scored per concentration.





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