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First published online September 7, 2006

Journal of Cell Science 119, 1802e (2006)
© The Company of Biologists Limited
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In this issue

Syntaxin 1A: sorting out neurotransmitters


Figure 1

Glutamate transporters, including excitatory amino-acid carrier 1 (EAAC1), prevent the overstimulation of nerve cells by mediating the reuptake of excitatory neurotransmitters at synapses. Because EAAC1 is also involved in the synthesis of the inhibitory neurotransmitter {gamma}-aminobutyric acid (GABA) at presynaptic terminals, it helps to maintain the balance between glutamate and GABA in the synaptic cleft. Since neurotransmitter imbalances cause epilepsy, establishing how EAAC1 activity is regulated is an important goal. On p. 3776, Lan Bao, Gang Pei and colleagues reveal that syntaxin 1A, a SNARE protein involved in membrane trafficking and neurotransmitter release, is involved in this regulation. They show that EAAC1 is endocytosed through the clathrin-mediated pathway and that syntaxin 1A potentiates its internalization. In addition, they find that knocking down endogenous syntaxin 1A by RNAi blocks endocytosis and degradation of EAAC1 induced by kainic acid (KA), which triggers epilepsy in rodents. Their results thus indicate that syntaxin 1A might be involved in epileptogenesis and identify the endocytic pathway in which it functions as a potential target for new treatment strategies.


Related articles in JCS:

Syntaxin 1A promotes the endocytic sorting of EAAC1 leading to inhibition of glutamate transport
Yong-Xin Yu, Li Shen, Peng Xia, Ya-Wei Tang, Lan Bao, and Gang Pei
JCS 2006 119: 3776-3787. [Abstract] [Full Text]  




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