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Fig. 4. Effect of the PLA₂ inhibitor AACOCF₃ on KCl-induced cytosolic Ca²⁺ transients in isolated FDB fibers from C57BL/6J and mdx^5cv mice. (A) KCl-induced cytosolic Ca²⁺ transients in isolated FDB fibers from C57BL/6J and mdx^5cv mice in control conditions and after preincubation of fibers with 50 µM AACOCF₃ for 10 minutes. (B) Plot of average [Ca²⁺]_i at the base line (b) and at the peak of KCl-induced Ca²⁺ transients (p) for both C57BL/6J and mdx^5cv fibers in control condition and in the presence of 50 µM AACOCF₃. (C) Plot of average half time of decay of KCl-induced Ca²⁺ transients in both types of fibers without and with 50 µM AACOCF₃. Data correspond to the fibers analyzed in B. Numbers of fibers tested (from two C57BL/6J mice and three mdx^5cv mice) are indicated on bar graphs.

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