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Fig. 5. Effect of the iPLA₂ inhibitor BEL on KCl-induced cytosolic Ca²⁺ transients in isolated FDB fibers from C57BL/6J and mdx^5cv mice. (A) KCl-induced cytosolic Ca²⁺ transients in isolated FDB fibers from C57BL/6J and mdx^5cv mice in control conditions and after preincubation of fibers with 5 µM BEL for 20 minutes (B) Plot of average [Ca²⁺]_i at the base line (b) and at the peak of KCl-induced Ca²⁺ transients (p) for both C57BL/6J and mdx^5cv fibers in control condition and after preincubation of fibers with 5 µM BEL. (C) Plot of average half times of decay of KCl-induced Ca²⁺ transients in both C57BL/6J and mdx^5cv fibers in control condition and after preincubation of fibers with 5 µM BEL. Data correspond to the fibers analyzed in B. (D) Acetylcholine (ACh)-induced cytosolic Ca²⁺ transients in isolated mdx^5cv FDB fibers in control condition and in fiber pretreated with 5 µM BEL for 20 minutes. Right panel: average half time of decay of ACh-induced Ca²⁺ transients in control and BEL-treated fibers. Numbers of fibers tested (from two C57BL/6J mice and three mdx^5cv mice) are indicated on bar graphs.

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