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Fig. 6. Store-operated Ca²⁺ entry in C57BL/6J and mdx^5cv fibers and effect of the iPLA₂ inhibitor BEL. Both types of fibers were preincubated with thapsigargin (1 µM) for 10 minutes in Ca²⁺-free solution prior to calcium re-addition (2 mM), leading to store-operated Ca²⁺ entry. (A) Ca²⁺ increases recorded in C57BL/6J and mdx^5cv fibers following preincubation with thapsigargin and Ca²⁺ re-addition. (B) Effect of the store-operated channel blocker BTP2 (5 µM, 10 minutes preincubation) on Ca²⁺ increases triggered by Ca²⁺ re-addition in both C57BL/6J and mdx^5cv fibers treated with thapsigargin. (C) Effect of the iPLA₂ inhibitor BEL (5 µM, 20 minutes preincubation) on Ca²⁺ increases triggered by Ca²⁺ re-addition in both C57BL/6J and mdx^5cv fibers treated with thapsigargin. (D) Average values showing the effect of BTP2, Gd³⁺ and BEL on store-operated Ca²⁺ entry in both types of fibers. Numbers of fibers tested (from five C57BL/6J mice and four mdx^5cv mice) are indicated on bar graphs.

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