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Figure 4


Fig. 4. Ultrastructural changes in Golgi organization during RII{alpha} depletion. HeLa cells were plated on a dish containing a single coverslip and incubated for 80 hours with siRNA specific for human RII{alpha}. The efficiency of depletion in the culture was first evaluated by immunofluorescence detection of RII{alpha} in cells attached to the coverslip. The rest of the cells were then fixed and processed for transmission electron microscopy. (A) General view of the cytoplasm of RII{alpha}-depleted cells. (B-D) Different Golgi stacks are shown. They appear as whorls composed of multiple concentrically arrayed cisternae. Cisternae appear dilated and fragmented. Bars, 0.5 µm.





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