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Figure 7


Fig. 7. Functional surfaces on the two helices forming the unique N-terminal region of PDE4A1. Shown in N- to C-terminal projections are three different visual orientations of the unique 25 amino acid N-terminal region of PDE4A1. These surface projections were generated in RasMol using the co-ordinates from the known structure derived by 1H-NMR (Brookhaven database pdb file 1LOI). In helix-2 the bilayer insertion module Trp19-Trp20 is indicated (W19:W20), together with the Ca2+-binding Asp21. In helix-1 the hydrophobic pocket formed from Leu3, Phe6 and Phe7 are displayed, together with the Ca2+-binding Asp5.





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