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Figure 3


Fig. 3. Cytochrome c is released from mitochondria in MEFs in response to ER stress. Apaf-1+/- MEFs were treated with either thapsigargin or tunicamycin for 24 hours. Cells were fixed and analyzed for intracellular localization of cytochrome c and BAX by immunofluorescence. Arrowheads show cells in which cytochrome c was released from mitochondria and BAX was translocated into mitochondria.





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