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Fig. 10. Sorting nexins in macropinosome maturation. Macropinosomes are formed at the base of actin-rich membrane ruffles in response to extracellular stimuli (EGF). The sorting nexins are rapidly recruited to discrete microdomains on the nascent organelle within the first few minutes following its formation. These microdomains traverse the surface of the macropinosome in a regulated and directed manner before being incorporated into highly dynamic tubular structures. The SNX-positive tubular structures extend from the macropinosome in a microtubule-dependent fashion eventually separating from the macropinosome and travelling along predefined paths towards the perinuclear region of the cell before fusing with acceptor early endosomes. Concurrent with the departure of the tubular structure is an increase in the apparent internal pressure of the donor macropinosome as well as a shift in its protein composition.
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