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Figure 10


Fig. 10. Erasin immunocytochemistry in Alzheimer's disease and neuropathologically normal control brain. Paraffin sections (5 µm thickness) of prefrontal cortex immunolabeled with erasin 141 antibody show immunostaining patterns in neurons and within the neuropil from different cases of neuropathologically normal controls (A-C) and moderate to severe AD (SAD) (D-I). Immunoreactivity in control brains is minimal (A-C). Counterstaining with thioflavin-S reveals the location of neurofibrillary tangles in one erasin-positive neuron (arrowhead, L,M) but not in another (arrow, M versus L) and the location of ß-amyloid peptide in a senile plaque (K) surrounded by erasin-positive dystrophic neurites (arrows in J). Bars, 5 µm.





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