spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

Right arrow Help viewing high resolution images
Right arrow Return to article
(Downloading may take up to 30 seconds.
If the slide opens in your browser, select File -> Save As to save it.)
Click on image to view larger version.


Figure 11


Fig. 11. Model for the role of DG as a MEC co-receptor in laminin-111 assembly and laminin-111-induced functions. {alpha}-DG on the MEC surface serves as the initial anchoring site for laminin-111 (LN) monomers by interacting with their C-terminal LG domains (step 1). The laminin-111-DG complexes recruit ß1 integrin (INT) co-receptors, which contribute to laminin-111 polymerization (step 2). Subsequent activation of co-receptors, possibly integrins (INT), influences intracellular signaling pathways leading to polarity and ß-casein induction (step 3).





Right arrow Return to article