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Figure 1


Fig. 1. Using BLAST, the closest homologs of IFTA-2 are human and mouse RabL5 proteins. IFTA-2, human RabL5, and mouse RabL5 share homology with human Rab15 and human Rab5A. Asterisks indicate identical residues in all species. Colons indicate conserved substitutions according to small and/or hydrophobic (AVFPMILW), acidic (DE), basic, (RHK) and hydroxyl/amine/basic/Q (STYHCNGQ) amino acids. Full stops indicate semi-conserved substitutions. G1, G2 G3 and G4 indicate conserved nucleotide-binding domains. Arrows indicate point mutations created in IFTA-2::GFP (T42N and D123L).





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