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Figure 4


Fig. 4. (A) Survival analysis on wild-type, osm-5(m184) and ifta-2(tm1724) strains show that ifta-2(tm1724) worms have a greatly extended lifespan compared with wild type. (B) Survival analysis shows that rescue of IFTA-2::GFP in ifta-2(tm1724) mutants results in greatly reduced lifespan compared with the original ifta-2(tm1724) mutant and is not different from wild type. IFTA-2::GFP in wild type is also similar to wild type, indicating that the transgene has no effect on lifespan. (C) Survival analysis shows that ifta-2(tm1724);daf-2(e1370) double mutants have a lifespan similar to that of daf-2(e1370) alone or ifta-2(tm1724) alone, indicating that there is no additive effect of the ifta-2 mutation on the daf-2 longevity phenotype. (D) Survival analysis shows daf-16 is epistatic to ifta-2 because ifta-2(tm1724);daf-16(mu86) double mutants have a lifespan similar to that of daf-16(mu86) alone and is reduced compared with the ifta-2(tm1724) alone. (E) Survival analysis shows osm-5(m184);ifta-2(tm1724) double mutants have a lifespan similar to that of ifta-2(tm1724) alone.





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