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Figure 5


Fig. 5. Loss of Pfn1 inhibits HUVEC migration in wound healing assay. (A) Representative images of the wound margins immediately and 12 hours after wounding show significant impairment in wound closure by HUVECs due to loss of Pfn1 expression (C, control siRNA; P, Pfn1-siRNA). Bar, 100 µm. (B) A higher magnification of the wound margin indicates closer association of Pfn1-deficient cells. Bar, 100 µm. (C) A bar graph plotting the relative efficiency of wound closure shows Pfn1-siRNA treatment inhibited wound-closure by 25%, 36% and 47% when evaluated at 48, 72 and 96 hours after transfection, respectively. (These data are summarized from three independent experiments and the asterisk indicates P<0.002.)





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