QUICK SEARCH:   [advanced] Author: Keyword(s):
Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents

First published online January 12, 2006

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?

Chaperoning yeast into mitosis

Molecular chaperones play essential roles in many aspects of cell function by ensuring that their client proteins fold properly and/or assemble into oligomeric structures. The clients of the molecular chaperone Cdc37 are generally protein kinases, and many of these are important for cell proliferation. Emma Turnbull, Ina Martin and Peter Fantes now report that Cdc2 – the pivotal cyclin-dependent kinase controlling the cell cycle – is a client of Cdc37 in fission yeast (see p. 292). They show that, at the restrictive temperature, Cdc37 function is rapidly lost in four temperature-sensitive mutants of cdc37 (cdc37^ts), all of which arrest in G2 phase within one cell cycle. Cdc2 activity, which normally regulates entry into mitosis, is also rapidly reduced at the restrictive temperature in two of these mutants and the authors show that this loss of activity results from the reduced ability of Cdc2 to bind its mitotic cyclin Cdc13. They conclude that, by interacting with Cdc2, Cdc37 aids the assembly of the Cdc2-Cdc13 complexes that are needed for cell-cycle progression.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

Related articles in JCS:

Activity of Cdc2 and its interaction with the cyclin Cdc13 depend on the molecular chaperone Cdc37 in Schizosaccharomyces pombe

Emma L. Turnbull, Ina V. Martin, and Peter A. Fantes
JCS 2006 119: 292-302. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?