QUICK SEARCH:   [advanced] Author: Keyword(s):
Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents

Help viewing high resolution images Return to article

Fig. 3. Bafilomycin A1 and nigericin abolish Ca²⁺ release responses from the thapsigargin-insensitive Ca²⁺ store. (A) Nigericin (7 µM) blocks NAADP (100 nM)-elicited Ca²⁺ release in the presence of thapsigargin (10 µM). (B) Nigericin does not block NAADP-elicited Ca²⁺ release in the absence of thapsigargin. (C) Nigericin blocks IP₃ (10 µM)-evoked Ca²⁺ release in the presence of thapsigargin. (D) Nigericin does not block IP₃-elicited Ca²⁺ release in the absence of thapsigargin. (E) Bafilomycin A1 (1 µM) abolishes NAADP-evoked Ca²⁺ release in the presence of thapsigargin. (F) Bafilomycin A1 fails to inhibit NAADP response in the absence of thapsigargin. (G) Bafilomycin A1 abolishes IP₃-evoked Ca²⁺ release in the presence of thapsigargin. (H) Bafilomycin A1 fails to inhibit IP₃ response in the absence of thapsigargin. Cells were loaded with Fluo-5N AM. All traces represent whole-cell regions of interest of permeabilized cells.

Return to article