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Fig. 2. Release of TCA-insoluble fragments is proportional to ß-subunit inhibition. (A-E) CFTR degradation was carried out at the indicated concentrations of MG132. The amount of total ({bullet}) and TCA-soluble ({circ}) fragments released from ER membrane was determined as in Fig. 1. TCA-insoluble fragments released are indicated by a double arrow.





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