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Fig. 8. Model of CD24 activity and CXCR4 function. In CD24–/– cells (N232.18 and 18H18– as well as in MDA-MB-231 CD24low cells) the CXCR4 receptor is more abundant in membrane rafts. As a result of this residence, CXCR4 signalling in response to SDF-1 triggers cell motility via ERK phosphorylation. In CD24+/+ cells (18H18+ and MDA-MB-231 CD24high cells), CXCR4 is excluded from lipid rafts and cannot transmit signals in response to SDF-1. This prevents ERK phosphorylation, blocks cell motility and attenuates tumour growth.





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