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Figure 6


Fig. 6. Schematic diagrams of {gamma}TuRC recruitment to interphase centrosomes, mitotic centrosomes during centrosome maturation, and to mitotic spindle MTs. (A) During interphase, centrosomal {gamma}-tubulin is exchanged with the cytoplasmic pool. (B) Additional {gamma}TuRC is recruited to centrosomes as cells enter mitosis in a process called centrosome maturation. During centrosome maturation, the interphase centrosome increases in size and recruits five times more {gamma}-tubulin. Concomitantly, five times more MTs are nucleated by the mature centrosomes. (C) During mitosis, {gamma}TuRC is recruited to centrosomes as well as to spindle MTs (indicated by arrows; notice that {gamma}TuRC is not drawn to scale). How {gamma}-tubulin is recruited to different sites and in a cell-cycle-dependent manner is only beginning to emerge. The mechanisms of {gamma}TuRC recruitment to centrosomes during interphase and mitosis are probably mediated by distinct sets of proteins (e.g. Casenghi et al., 2003).





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