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Figure 3


Fig. 3. Histomorphometric characterization of osteopenia in conditionally osteoblast Cx43-deleted mice. (A) Trichrome Masson stain of 4 µm undecalcified sections of proximal tibiae from mice of the three different genotypes at 6 months. (B-G) Quantitative histomorphometry showing significantly lower bone volume/total volume, osteoblast number and trabecular thickness in the ColCre;Cx43–/fl, with non-statistically different trabecular number, mineral apposition rate and osteoclast number among the three genotype groups. *P<0.05 versus Cx43+/fl (one-way ANOVA); n=6 per genotype group.





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