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Figure 6


Fig. 6. Region-specific changes in BMC in osteoblast Cx43-deficient mice. (A) Percent change from baseline of whole body BMC after a 4-week treatment with 40 µg/kg PTH in a group of 7.4-9.6-month-old mice, showing an attenuated response in conditionally deleted ColCre;Cx43–/fl mice (n=10) relative to wild-type animals (n=15), whereas response in Cx43–/fl mice (n=11) was intermediate. (B) Response was absent at the lumbar spine in both ColCre;Cx43–/fl and heterozygous equivalent Cx43–/fl. (C) Significant increases in bone mass were instead detected in all genotypes on the total femoral area. **P<0.01, *P<0.05 versus vehicle (n=9); #P<0.05 versus ColCre;Cx43–/fl; one-way ANOVA.





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