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Figure 7


Fig. 7. Influence of ZnT-8 on glucose-induced insulin secretion. INS-1E-EGFP and INS-1E-ZnT-8-EGFP cells were used to assess insulin secretion in response to glucose. After incubation in glucose-free buffer (see Materials and Methods), cells were exposed to different concentrations of glucose for 30 minutes. Intracellular and secreted insulin were measured by ELISA. White bars, control cells; gray bars, INS-1E-ZnT8-EGFP cells. Values are the mean ± s.e.m. of at least five experiments, *P<0.01 vs control, **P<0.005 vs control.





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