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Figure 11


Fig. 11. Summary of principal features of putative sites of lipid droplet biogenesis in ER. Lipid droplet biogenesis takes place at specialized cup-shaped regions of the ER. The lipid droplet is cupped by closely apposed ER membrane outside the ER. Adipophilin (dark red) is highly concentrated in the cytoplasmic leaflet of the ER membrane of the cup immediately adjacent to the lipid droplet, and in the envelope of the lipid droplet. Lower concentrations of adipophilin (pink) are found in the cytoplasmic leaflets of ER membranes, but not in endoplasmic leaflets (gray).





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