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Figure 3


Fig. 3. Trafficking of GFP-CPS, UbGFP-CPS and GFP-Sna3p in vps27{Delta}, vps4{Delta} and fab1{Delta}/vps4{Delta} cells. Cells were transformed with plasmids for expressing GFP-CPS, UbGFP-CPS or GFP-Sna3p, grown to mid-exponential phase and inspected by light and fluorescence microscopy. In all three mutants cargo proteins predominantly localize to the swollen MVB characteristic of class-E mutants. Thus, unlike in AP-1 complex component and fab1 mutants, UbGFP-CPS and GFP-Sna3p do not traffic to the vacuole lumen in vps27{Delta}, vps4{Delta} and fab1{Delta}/vps4{Delta} cells.





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