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Fig. 4. Motor coordination is altered in L7-pepE mice. (A) Upper panel, representative footprint patterns of a wild-type and a L7-pepE mouse. Lower panel, comparison of step widths, step lengths and maximum differences in stride length (mdsl) between wild-type (black bars; n=20) and Tg-2 (grey bars; n=20) animals. Locomotion is similar in both groups and no ataxic phenotype is observed. (B) Vertical pole scores (means ± s.e.m.), recorded as described in Materials and Methods, are reported for wild-type (black bars; n=23), Tg-2 (light grey bars; n=23) and Tg-1 (dark grey bars; n=10) mice. Each animal was tested in three consecutive trials. *P<0.05, Newman-Kleus multiple comparison test. (C) Rotarod performance of wild-type (
, n=9), Tg-1 (
, n=9) and Tg-2 (
, n=8) mice in the constant speed mode. The time (means ± s.e.m.) mice remained on the rotating rod at the various speeds are reported. *P<0.05, Newman-Kleus multiple comparison test. Inset, rota-rod motor learning of wild-type (, n=10) and Tg-2 (, n=10) mice in the constant acceleration mode. Individual learning curves were fitted using linear regression [Y-intercept, 162±19 for WT mice and 151±19 for Tg-2 mice (P=0.7); slope, 11.2±3.3 for wild-type mice and 1.5±2.9 for Tg-2 mice (P<0.05)]. The performances in the initial and final trials of the learning curve were significantly different only in wild-type mice (P<0.005), but not in Tg-2 mice (P=0.26, Student's t test).
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