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Figure 6


Fig. 6. Depression induced by short trains at 100 Hz is less intense in L7-pepE mice. (A) Whole-cell patch-clamp recordings of P8-P10 DCN neurons from wild-type (left panel) and Tg-2 (right panel) mice. IPSC trains were obtained by stimulating PC axons at 100 Hz for 200 milliseconds. Facilitation is apparent and depends on temporal summation of IPSCs. Each train is the average of ten tracings to reduce synaptic variability. (B) Average of independent recordings performed as described above in wild-type ({circ}, n=4) and Tg-2 (bullet, n=4) mice. Amplitudes were normalized to the first IPSC and fittings were performed with an exponential function of the form y(t)=Axe–t/{tau}+y0. Note the slower depression and the higher steady-state level observed in mutant animals. (C) Time constant ({tau}) and steady-state amplitude (y0) of depression are shown as means ± s.e.m. for wild-type (white bars; n=4) and Tg-2 (black bars; n=4) mice. *P<0.05, Student's unpaired t test.





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