spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

Right arrow Help viewing high resolution images
Right arrow Return to article
(Downloading may take up to 30 seconds.
If the slide opens in your browser, select File -> Save As to save it.)
Click on image to view larger version.


Figure 7


Fig. 7. L7-pepE PC terminals exhibit milder depression and faster recovery after prolonged high-frequency stimulation. (A) Effect of prolonged stimulation trains (50 Hz for 2 minutes) on IPSC amplitude. A representative experiment shows the faster and more intense synaptic depression in wild-type mice (left) with respect to Tg-2 mice (right). (B) Left panel, IPSC amplitudes during the prolonged stimulation are expressed in percent of the first IPSC. The IPSC decrease was smaller in L7-pepE (bullet, n=4) than in wild-type ({circ}, n=5) mice. Statistical analysis was performed on the steady-state levels (50-120 seconds) using the Student's unpaired t test (P<10–8). Right panel, the number of failures during prolonged stimulation trains was lower in L7-pepE (bullet, n=4) than in wild-type ({circ}, n=5) mice. Data are reported as means ± s.e.m. Statistical analysis was performed on the steady-state levels (50-120 seconds) using the Student's unpaired t test (P<10–13).





Right arrow Return to article