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Figure 8


Fig. 8. The kinetics of release is faster in L7-pepE mice. (A) Representative IPSCs recorded from DCN neurons from wild-type and Tg-2 mice. IPSC traces were normalized to identical peak amplitudes. (B) Representative IPSCs recorded from PC-DCN synapses showing the shortening of the synaptic delay in IPSC in Tg-2 mice with respect to wild-type mice. (C) The histogram shows the mean values (± s.e.m.) for IPSC rise, decay and delay times obtained from wild-type (white bars; n=9) and Tg-2 (black bars; n=7) mice. IPSC rise time was measured as the time needed to rise from 10% to 90% of peak amplitude. IPSC decay time was evaluated by exponential fitting of the decay with the exponential function y(t)=Axe–t/{tau}. Statistical analysis was performed using the Student's unpaired t test; *P<0.05.





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