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Figure 9


Fig. 9. SV density and distribution is altered in L7-pepE mice. (A) Representative electron micrographs of PC terminals on DCN somata from wild-type (WT, left panel) and Tg-2 (right panel) mice. Bar, 1 µm. (B) Distribution of SVs in PC terminals from wild-type (black bars; n=60) and Tg-2 (grey bars; n=54) mice. The absolute number of SVs (means ± s.e.m.) located within successive 50 nm shells from the active zone (AZ) is shown. The frequency distribution of SVs as a function of the distance from the AZ was analyzed using the Kolgomorov-Smirnov and Mann-Whitney tests; P<0.05 for the 50-100 nm shell; P<0.01 for the intervals between 400 and 1400 nm. Inset, to analyze the distribution pattern of SVs, the number of SVs in the various shells was expressed in percent of the total SV number for each PC terminal of wild-type (WT, upper panel) and Tg-2 (lower panel) mice. The solid traces and dotted lines represent the mean and s.e.m. values, respectively.





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