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Figure 5


Fig. 5. Altering Rheb-TOR-S6K signaling can influence the response of adult flies to starvation stress. (A) The mean survival 24 hours after the start of PBS starvation is 83% for hsGAL4/w flies and 98% for daGAL4/w flies, but only 12% for hs>Rheb flies (n=100, P=0.0339) and 5% for da>S6KSTDETE flies (n=100, P=0.0136). (B) The mean survival 36 hours after the start of PBS starvation is 66% for da>Tsc2 flies (n=110, P=0.0059) and 100% for hs>S6KKQ flies (n=117, P=0.0019), but only 20% for hsGAL4/w flies (control) and 23% for daGAL4/w flies (control). Error bars represent the s.d. Statistical comparison (T-test): all P values are based on comparison of the overexpressor with controls (hsGAL4/w and daGAL4/w).





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