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Figure 1


Fig. 1. The PAR polarity complex is localized at the apical membrane of NEP cells. (A) Deduced protein sequence of cPAR3, depicting the aPKC, KIF3A and TIAM1 binding domains (aPKC-BD; KIF3A-BD; TIAM1-BD). (B) Endogenous cPAR3 localizes apically in NEP cells (a). cPAR3 localizes basally to cPAR6 (b,c) and aPKC (d). cPAR6 colocalizes with aPKC (e). (C) cPAR3 colocalizes with N-Cadherin, Afadin and ß-Catenin at the apical tip of NEP cells (a-c). cPAR6 and aPKC are located apically relative to N-Cadherin (d,e). (D) cPAR3 is localized basally relative to both cPALS1 and cCRB3 (a,b). cPAR6 colocalizes apically with cCRB3 (c). (E) LGL1 localizes basolaterally and is absent from the apical cPAR3 accumulation domain (a). (F) Schematic representation of the localization of polarity proteins in NEP cells. L, lumen of the NT. Bars in (Ba,b,d,e;C;Db,c;E), 2 µm; bar in (Bc), 3 µm; bar in (Da), 1 µm.





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