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Figure 5


Fig. 5. Ectopic cPAR3 is sufficient to mislocalize polarity and junction-associated proteins in NEP cells. At the electroporated side of the NT, N-Cadherin accumulates ectopically (white bracket in A,A'), colocalizing with cPAR3::GFP punctates (arrowheads in B,B'). The same applies to ß-Catenin (arrowheads in C-D') and aPKC (arrowheads in E-F'). Triple-labelling of cPAR3, cPAR6 and aPKC shows colocalization at ectopic clusters (G,G'). Members of the CRB complex also mislocalize to cPAR3 punctates (arrowheads in H-K'). (L) LGL1 is excluded from the ectopic sites of cPAR3 accumulation at the lateral membrane (arrowheads). b, basal side of the NE. Magnification in (A,A',C,C',E,E',H,H',I,I'), 40x. Bars in (B,B',G,G'), 2 µm; bars in (D,D',F,F',J,J',K,K'), 10 µm; bar in (L), 1 µm.





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