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Figure 2


Fig. 2. Glycan processing determines the fate of the associated polypeptide chain. After addition of the pre-assembled oligosaccharide the two outermost glucoses are removed (step 1) and the nascent polypeptide associates with calnexin/calreticulin (Cnx) and the oxidoreductase ERp57. Most glycopolypeptides are probably released as native proteins (step 2) and exit the ER (step 3). Folding-defective polypeptides enter cycles of dissociation/re-association (steps 2a, 4 and 5) with Cnx. Folding attempts are eventually interrupted upon extensive substrate demannosylation and terminally misfolded polypeptides are retrotranslocated into the cytosol and degraded (step 6).





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