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Figure 3


Fig. 3. Molecular composition of domains at the node of Ranvier. Components of the nodes include neurofascin-186, NrCAM and voltage-gated Na+ channels, which are tethered to a complex containing ankyrin G and ßIV-spectrin. The paranodes contain a complex of Caspr, contactin and 4.1B at the axonal membrane, which binds to neurofascin-155 on the paranodal loop. The multiprotein complex in the juxtaparanode contains a cis complex of Caspr2 and TAG-1, which interact with 4.1B and a PDZ-domain-containing protein associated with the two shaker-type K+ channels, Kv1.1 and 1.2. This complex is linked through a trans interaction with TAG-1 to the glial membrane.





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