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Figure 7


Fig. 7. Loss but not overexpression of Dlg affects Gliotactin localization. (A,B) Gliotactin is mislocalized in Dlgm52 mutant imaginal discs. Imaginal discs were isolated from second instar (A) and third instar (B) larvae homozygous from Dlgm52 and stained for Gliotactin (green), Dlg (red) and E-cadherin (blue). Arrows in A indicate puncta of staining remaining. (C,D) Gliotactin localization is normal when Dlg is overexpressed. Dlg-A fused to GFP was driven to high levels in the imaginal disc using patched-GAL4. Gliotactin (green) and Spectrin (red) were used to highlight the TCJ and cell boundaries, respectively. DlgGFP (blue) was localized to the TCJ in peripodial cells (C, arrows) and to the SJ domain in columnar epithelia (D). DlgGFP did spread down the SJ domain when overexpressed (D) but had no effect on cell morphology or Gliotactin localization. Bars, 15 µm.





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