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Figure 8


Fig. 8. Model for the effects of platelet DAB2 on platelet aggregation. DAB2 is secreted from platelets upon agonist-induced platelet aggregation. Secreted DAB2 binds to the extracellular region of {alpha}IIb integrin and interferes with the {alpha}IIbß3-integrin–fibrinogen interaction that results in the inhibition of platelet aggregation. Whether or not Ser24 phosphorylation of platelet DAB2 plays a role during platelet activation and aggregation still needs to be established.





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