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Figure 2


Fig. 2. Nestin-cre reduces Cx43 expression in the ciliary epithelium and iris by embryonic day 16-18. Eyes from nestin-cre/Cx43+/flox (A,B) and nestin-cre/Cx43flox/flox (C,D) mice were harvested, treated and sectioned as described in Materials and Methods section. Photomicrographs of immunostaining using anti-Cx43 antibody (A,C) and H and E stained (B,D) sections from the same specimens were taken. (A) In the heterozygote, Cx43-positive staining is seen in the ciliary epithelium (CE) and presumptive iris (PI) and in the corneal epithelium (ep) and endothelium (en) and the retinal pigment epithelium (RPE). The lens staining is non-specific (see Fig. 3). (C) In the homozygote, a reduction of staining is evident in the ciliary epithelium and presumptive iris. Bars, 20 µm.





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