spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

Right arrow Help viewing high resolution images
Right arrow Return to article
(Downloading may take up to 30 seconds.
If the slide opens in your browser, select File -> Save As to save it.)
Click on image to view larger version.


Figure 7


Fig. 7. Schematic representation for the proposed mechanism in the migratory process involving trophoblast cells. The interaction of the gC1q1 domain of EMILIN1, produced by decidual stromal cells, with {alpha}4ß1 promotes trophoblast migration towards the vessels. The engagement of {alpha}4ß1 also promotes the release from trophoblast cells of MT1-MMP (60 kDa form) that in turn activates MMP-2 on the membrane of stromal cells. The activated enzyme could digest the ECM component of blood vessels (i.e. laminins), exert an improved efficiency in binding capability or signaling functions of the {alpha}4ß1 receptor, or unmask EMILIN1 cryptic sites in order to facilitate the migratory phenotype of trophoblast cells. The potential role of FN and other ECM molecules and of integrins other than {alpha}4ß1 is not represented for clarity.





Right arrow Return to article