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First published online October 30, 2006

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How the spindle is Glue(d) together...

Dynein-dynactin motor complexes are involved in several stages of mitosis. For example, they remove checkpoint proteins from correctly attached kinetochores (the complexes that attach chromosomes to the spindle) by transporting them away along microtubules. Régis Giet and co-authors have now re-investigated the roles of dynein-dynactin complexes in mitosis and cytokinesis by knocking down the dynactin subunit p150^Glued by RNAi in Drosophila S2 cells (see p. 4431). They show that p150^Glued is required for connection of centrosomes to spindle poles, the metaphase-to-anaphase transition, and synchronous chromosome movements during anaphase. Then they show that p150^Glued facilitates formation of the central spindle by increasing the efficiency of recruitment of the mitotic kinases Aurora B and polo to the midzone. p150^Glued is also needed, the authors report, to recruit Pavarotti-KLP (a component of the centralspindlin complex that is required for cytokinesis) efficiently to the central spindle microtubules. Their results thus confirm the involvement of the dynein-dynactin complex during mitosis and also reveal new roles for it during cytokinesis.

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Related articles in JCS:

Dynactin targets Pavarotti-KLP to the central spindle during anaphase and facilitates cytokinesis in Drosophila S2 cells

Jean-Guy Delcros, Claude Prigent, and Régis Giet
JCS 2006 119: 4431-4441. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?