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First published online October 30, 2006

Journal of Cell Science 119, 2103e (2006)
© The Company of Biologists Limited
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In this issue

...and produces a GAP in the furrow


Figure 1

During cytokinesis, a cleavage furrow forms at the equator of the cell and partitions its cellular components between its progeny. Spindle microtubules determine the position of the cleavage plane. But do they directly trigger furrow formation or deliver a signal to the cortex to initiate the necessary cytoskeletal rearrangements? On p. 4402, Pier Paolo D'Avino and colleagues provide strong evidence supporting the second possibility by showing that microtubule-mediated delivery of the GTPase-activating protein (GAP) RacGAP50C signals furrow formation during cytokinesis in flies. RacGAP50C and the motor protein Pavarotti are part of the centralspindlin complex necessary for cytokinesis. The authors show that depletion of either component prevents furrowing without affecting the association of spindle microtubules with the cell cortex. They then show that these microtubules deliver the centralspindlin components to the cortex just before furrow formation. Finally, they demonstrate that mislocalization of RacGAP50C causes ectopic furrowing even in the absence of Pavarotti. Thus, the GAP component of centralspindlin appears to be both necessary and sufficient to signal furrow formation during cytokinesis.


Related articles in JCS:

RacGAP50C is sufficient to signal cleavage furrow formation during cytokinesis
Pier Paolo D'Avino, Matthew S. Savoian, Luisa Capalbo, and David M. Glover
JCS 2006 119: 4402-4408. [Abstract] [Full Text]  




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