QUICK SEARCH:   [advanced] Author: Keyword(s):
Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents

First published online October 30, 2006

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?

DABbling with integrin function

Platelet aggregation plays an important role in blood clotting. When a blood vessel is damaged, platelets are recruited to the injured endothelium, where they release coagulation factors and platelet activation factors from their and granules. Interactions between fibrinogen and integrin IIbß3 on the surface of platelets then induce platelet aggregation, which helps to form a clot. On p. 4420, Ching-Ping Tseng and colleagues reveal that the adaptor protein, Disabled-2 (DAB2) negatively regulates these interactions by binding to IIb integrin on the platelet surface. DAB2 is best known as a cytoplasmic adaptor. The authors now show that it is also present in platelet granules. During platelet activation, they report, DAB2 is released and binds to the extracellular region of IIbß3 integrin. Because this binding involves the part of IIb integrin that binds to fibrinogen, DAB2 blocks the platelet-fibrinogen interaction and thus inhibits platelet aggregation. The authors propose therefore that DAB2 helps to regulate the size of platelet aggregates, which could prevent excessive clotting.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

Related articles in JCS:

Disabled-2 is a novel IIb-integrin-binding protein that negatively regulates platelet-fibrinogen interactions and platelet aggregation

Chien-Ling Huang, Ju-Chien Cheng, Arnold Stern, Jer-Tsong Hsieh, Chang-Hui Liao, and Ching-Ping Tseng
JCS 2006 119: 4420-4430. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?