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Figure 1


Fig. 1. Classification, domain structure and phylogenetic analysis of the dual-specificity MAPK phosphatases. (A) Domain structures of the ten catalytically active DUSP proteins and MK-STYX. In addition to the N-terminal non-catalytic domain containing the Cdc25/rhodanese-homology region and the catalytic site, the positions of the conserved kinase-interaction motif (KIM), nuclear localisation signals (NLS), nuclear export signals (NES) and PEST sequences are indicated. The three subgroups revealed by the phylogenetic analysis are indicated by the background colour. (B) DUSP sequence analysis. Human DUSP amino acid sequences were aligned using CLUSTALW (http://align.genome.jp/) and a phylogenetic tree was generated. The three subgroups of DUSP proteins together with defining properties are indicated by the coloured ovals.





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