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Figure 5


Fig. 5. Proposed mechanism of action of p63 upstream of IKK{alpha}. TAp63{alpha} and {Delta}Np63{alpha} have different, synergistic functions in the formation of the epidermis; TAp63 exerts its effects, at least in part, by acting directly upstream of IKK{alpha} (which is also indirectly transactivated via Ets-1 and GATA-3), whereas {Delta}Np63 can only activate IKK{alpha} indirectly, at least partly via GATA-3. bm, basal membrane; bl, basal layer of keratinocytes; CE, cornified envelope.





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