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Figure 4


Fig. 4. Restoration of replication activity in HGPS cells by inactivation of ATM and ATR. (A) Western blotting shows the knockdown of ATR and ATM in BJ and HGPS cells by RNAi. ß-actin was used as sample loading control. (B) The replication assay was performed with [methyl-3H]-thymidine labeling as described in Materials and Methods. BJ cells and HGPS cells used were at passage 12. The asterisk indicates a significant difference, P<0.05.





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