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Figure 8


Fig. 8. Overexpression of GRIF1 inhibits EGF-induced EGFR degradation. (A) HeLa cells transfected with pCHA-GRIF1 or pCHA vector were incubated in the presence or absence of 100 ng/ml EGF for 1 hour at 37°C. Equal amounts of proteins from cell lysates were analyzed by immunoblotting with antibodies against EGFR (top), HA (middle), or actin (bottom). (B) The degraded EGFR is expressed as a percentage of the EGFR level in the corresponding untreated cells. Data represent mean ± s.e.m. from three independent experiments. The asterisk indicates a statistically significant difference (P<0.05) from the vector-transfected cells.





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