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Figure 7


Fig. 7. Morphology, subdomain architecture and molecular components of AJCs and TAJs. (a) Diagram of a canonical AJC depicting a TJ and an AJ. The TJ comprises claudin-based anastomosing contacts between adjacent cell membranes. A ZO-1 scaffold assembles the underlying dense plaque and recruits a discrete actin cytoskeletal network. The AJ comprises a belt of cadherin-based transmembrane bridges and a catenin molecular complex assembles the underlying dense cytoplasmic plaque and recruits an extensive actin cytoskeletal network. (b) Diagram of a unitary, hybrid tight-adherens junction (TAJ) at the DC-OHC interface. The apical-most region of the TAJ is a claudin-14-rich subdomain of parallel TJ strands and the underlying ZO-1 scaffold assembles a small actin cytoskeletal network. A second subdomain enriched in claudin-9/6 forms an extensive belt of anastomosing membrane contacts. The underlying ZO-1 scaffold and the catenin molecular complex assemble a dense cytoplasmic plaque and recruit an extensive actin cytoskeletal network. The dense cytoplasmic plaque is localized to TAJs at a location that is analogous to their classical location in the canonical AJC.





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