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Figure 5


Fig. 5. ChlR1 depletion results in mitotic failure. (A) Normal nuclear morphology in uninduced RPE1-TetR-ChlR1 cells (B) RPE1-TetR-ChlR1 cells were induced with 2 µg/ml doxycycline for 96 hours. Representative nuclear abnormalities are indicated (1-4) and enlargements are shown below. {alpha}-Tubulin was stained red and DNA stained blue. Bar, 40 µm except for enlargements. (C) Quantification of nuclear abnormalities before and after induction of ChlR1 shRNA. Cells within a field of view were counted and the percentage of nuclear abnormalities determined and classified as fragmented (grey) or abnormally large (white). Data are the average of ten fields of view for each sample.





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