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Figure 2


Fig. 2. ERK2-GFP concentrates in the nucleus of living cells after stimulation. (A) Nuclear fluorescence increased within 4 minutes from stimulation with 10% serum. Bar, 10 µm in all panels. (B) Cumulative time course of the CI after stimulation with FGF4 (blue, n=9; ERK1-KD, red line, n=4) or 10% serum (green symbols, n=15; C-ERK2, dark-green line, n=6). In this and following figures, the vertical bars are representative of the s.e.m. at various time points. (C,D) The CI after stimulation with serum had a transient component (30% decline 40 minutes after stimulation), whereas FGF4 produced a sustained response. (E) Time course of ERK2-GFP nuclear concentration after stimulation with two different doses of serum (green, 10%, n=7; yellow, 1%, n=8) and FGF (blue, n=8). Red trace, untreated control cells (n=9).





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