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First published online November 27, 2006

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ß-catenin flexes its muscles

Canonical Wnt signalling plays many important roles during embryogenesis. During myogenesis, for example, the stabilization of ß-catenin by Wnt signalling activates the transcription factor TCF/LEF-1, which upregulates the expression of myogenic regulatory factors (MRFs). On p. 4850, Lin Li and co-authors identify a second role for ß-catenin in myogenesis. They show that it also counteracts the effect of I-mfa, a transcriptional repressor that inhibits expression of both TCF/LEF-1 and MRFs. ß-catenin interacts with I-mfa and relieves I-mfa-mediated suppression of MRFs. The authors show that endogenous I-mfa suppresses myogenesis in pluripotent P19 carcinoma stem cells by inhibiting the expression of TCF/LEF-1. ß-catenin, they report, competes with I-mfa for binding to TCF/LEF-1 and thus relieves the inhibitory effects of I-mfa overexpression on myogenesis. The dual mechanism by which ß-catenin regulates TCF/LEF-1-dependent transcription, suggest the authors, might help to fine-tune cellular responses to changes in Wnt signalling during development and other physiological processes and during pathological processes such as cancer.

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ß-catenin relieves I-mfa-mediated suppression of LEF-1 in mammalian cells

Weijun Pan, Yingying Jia, Tao Huang, Jiyong Wang, Donglei Tao, Xiaoqing Gan, and Lin Li
JCS 2006 119: 4850-4856. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?