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First published online November 27, 2006

Journal of Cell Science 119, 2302e (2006)
© The Company of Biologists Limited
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In this issue

ß-catenin flexes its muscles


Figure 1

Canonical Wnt signalling plays many important roles during embryogenesis. During myogenesis, for example, the stabilization of ß-catenin by Wnt signalling activates the transcription factor TCF/LEF-1, which upregulates the expression of myogenic regulatory factors (MRFs). On p. 4850, Lin Li and co-authors identify a second role for ß-catenin in myogenesis. They show that it also counteracts the effect of I-mfa, a transcriptional repressor that inhibits expression of both TCF/LEF-1 and MRFs. ß-catenin interacts with I-mfa and relieves I-mfa-mediated suppression of MRFs. The authors show that endogenous I-mfa suppresses myogenesis in pluripotent P19 carcinoma stem cells by inhibiting the expression of TCF/LEF-1. ß-catenin, they report, competes with I-mfa for binding to TCF/LEF-1 and thus relieves the inhibitory effects of I-mfa overexpression on myogenesis. The dual mechanism by which ß-catenin regulates TCF/LEF-1-dependent transcription, suggest the authors, might help to fine-tune cellular responses to changes in Wnt signalling during development and other physiological processes and during pathological processes such as cancer.


Related articles in JCS:

ß-catenin relieves I-mfa-mediated suppression of LEF-1 in mammalian cells
Weijun Pan, Yingying Jia, Tao Huang, Jiyong Wang, Donglei Tao, Xiaoqing Gan, and Lin Li
JCS 2006 119: 4850-4856. [Abstract] [Full Text]  




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