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Figure 5


Fig. 5. In mammals, a continuous protein scaffold connects the extracellular matrix to the nuclear lamina via IFs and F-actin. Integrin {alpha}6ß4, present in hemidesmosomes (HDs), and ß1/ß3 integrins, present in focal contacts (FCs), connect the extracellular matrix (ECM) to cytoplasmic IFs (via plectin) and F-actin (via talin), respectively. These two cytoskeletal systems are interconnected to each other via the plakins (yellow circles) or to themselves via filamin or {alpha}-actinin (red circles) and the plakins (grey circles). F-actin associates with the ABDs of nesprin-1 and nesprin-2; IFs associate with plectin dimers bound to nesprin-3. In turn, the ONM nesprins associate with either SUN1 or SUN2 within the PS. The INM SUN-domain proteins associate with lamin A through their N-termini within the nucleus. ER, endoplasmic reticulum; INM, inner nuclear membrane; ONM, outer nuclear membrane; PM, plasma membrane; PS, periplasmic space.





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